results.2,8
the .S. Food and Dru Administration has reuired that uncooked cereal rains and our products be ortied ith olic acid. 8
hile insucient olate can result in atiue, depression, conusion, anemia, reduced immune unction, loss o intestinal illi, and an increase in inections,2,5,6
conditions that ould hae otherise beneted rom real ood olate. Furthermore, ery lare amounts o olic acid in its pharmacoloical oxidied (PA) orm may be noxious to the nerous systemand hae prooked seiures in patients otherise under control on anticonulsant therapy.2
Folic acid is placed in certain rened rain products to help ortiy the itamin content. oeer, as the renin process tends to reduce ber, protein, and natural B itamin leels, it ould seem iser to consume oods that hae not been as rened.
Excessive Folic Acid is Becoming a Health Concern
A 2010 report states, The more e learn about olic acid, the more it’s clear that iin it to eeryone has ery real risks, says olic acid researcher Daid Smith, PhD, a proessor o pharmacoloy at the niersity o Oxord in Enlandthe risk experts orry about most: colon cancer. ast year, health ocials in Chile reported that hospitaliation rates or colon cancer amon men and omen ae 45 and older more than doubled in their country since ortication as introduced in 2000. n 2007, oel Mason, MD, director o the Vitamins and Carcinoenesis aboratory at the Tuts niersity School o Medicine, described a study o the nited States and Canada suestin that rates o colon cancer rose - olloin years o steady decline - in the late 1990s (around the time our ood as bein ortied).14
The same report also states, Other research links hih doses to lun and prostate cancers. n one study conducted in Noray, hich doesn’t ortiy oods, supplementation ith 800 mc o olic acid (plus B12 and B6) daily or more than 3 years raised the risk o deelopin lun cancer by 21 percent. Another, in hich men took either olic acid or a placebo, shoed those consumin 1,000 mc o olic acid daily had more than tice the risk o prostate cancer. And a ne orry recently came to liht hen scientists discoered the lier has limited ability to metabolie olic acid into olate hich means any excess continues circulatin in the bloodstream. nlike olate, olic acid isn’t ound in nature, so e don’t kno the eect o the excess, says Smith. ndeed, many scientists hae ron increasinly concerned about mountin research includin a study published last inter in the ournal o the American Medical Association suestin that all the extra olic acid miht increase your odds o deelopin cancer.14
THE ORIGINAL INTERNIST NE 2016
consumption o olic acid may actually interere ith olate metabolism2
Certain scientists beliee that excessie this could be expected to orsen
totally clear hat daners lon-term consumption o olic acid ill cause.2,8
it is not
deriaties act to inhibit certain enymes, includin those associated ith nucleotide biosynthesis.8
Also, in itro studies do sho that PA n spite o this,
A maor placebo controlled trial ound that men ho took olic acid ere about three times as likely to deelop prostate cancer as men ho did not.15
suested that olates in ood helped reduce the risk or prostate cancer.
That same trial
At least one study inolin breast cancer as een less conclusie, but had ndins that hinted that reduction in olic acid consumption may possibly reduce the risk.16 hile hiher dietary olate intake may be associated ith a loer risk o breast cancer,17
case ith olic acid. One study, or cancer suriors, ound that Folic acid supplement use as associated ith hiher risk o death, only amon suriors reportin lo-uality diets.18
Some studies shoed a hiher risk o breast cancer in populations exposed to hih olate intake post ortication, especially hen olic acid is used. The results support the need to be cautious and to limit the exposure o omen to hih intakes o olic acid, especially in countries ith mandatory ood ortication.19 hae mandatory ortication.)
A study inolin 38,772 omen in the SA ho took synthetic multi-itamin ormulas ound that, on aerae, omen died seeral years earlier than those ho did not take them, and olic acid as identied as a possible reason.20
ood itamins and minerals are essential to human health and promote loneity.
Foods ortied ith olic acid may cause serious neuroloical problems in patients decient in itamin B12.12
to be more bioaailable than natural sources, it also seems to be much less sae.15
the eects o lielon consumption o oods ortied ith olic acid, it ould seem to be better not to take additional olic acid in the orm o nutritional supplements or most people
Researchers R. yer and S. Tomar rihtly concluded, A number o studies hae shon that hih intakes o olic acid, the chemically synthesied orm, but not natural olates, can cause aderse eects in some indiiduals such as the maskin o the hematoloical maniestations o itamin B12 deciency, leukemia, arthritis, boel cancer, and ectopic prenancies.22
that ood orms ere preerred or prenant omen.22 They also concluded
researcher’s ie is that toxicity plays a role and it may be that excessiely hih intakes o olic acid increase that risk.
n 2016, ohns opkins said that it appears that too much olic acid can possibly cause (or at least contribute to) autism.23
hile causes or autism can be debated, this
(Continued on page 61) 59
No, this is not to say that olic acid uniormly causes neuroloical problems or increases cancer rates or eeryone,21
but since it ill take a lon time to determine
as truly sae in the presence o untreated cobalamin deciency.12
Furthermore, no olic acid dose can be considered Althouh synthetic olic acid is considered
Synthetic itamins are danerous. et, 100 the same is not the
(Countries like the SA
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