olic cid s Danrous ut olats ound in oods r Halth
by: Robert Thiel, Ph.D., Nutrition Scientist and Clinician
Abstract
For many years, public health ocials hae adocated the consumption o olic acid. Folic acid is a synthetic substance that as deeloped in the 20th century. Folic acid is chemically knon as pteroyllutamic acid and is a crystalline substance. Folates ere once also knon as itamin B9. Folates exist in oods, yet crystalline olic acid does not. Research suests that olic acid consumption may orsen, or een cause, some types o cancer and contribute to the orsenin o certain neuroloical conditions. Folates in ood, hoeer, hae not been shon to be danerous. nstead olates ound in oods are belieed to help build and maintain health. umans should rely primarily on natural hole oods or their olate needs, and i more is needed, take nutritional supplements that supply olates, not synthetic olic acid.
Vitamin B9, Folate
n the 1930s, it as discoered that there as a substance in lier that reersed meablastic anemia that as independent o cobalamin (sometimes called itamin B12).1
reerred to as olate (thouh there are multiple olates) or olacin. Early on, ood olate as ien or people ith a prenancy-related anemia in the orm o autolyed yeast later the synthetic orm, olic acid, as deeloped.2
o olate ound in human plasma.1
Folate unctions as a co-enyme. Dierent olate orms are important or the synthesis o thymidine or DNA and purines or RNA.1
best ood supplement source by some. Furthermore, olates are ubiuitous in nature, bein present in nearly all natural oods50 to 95 o olate in ood may be destroyed by protracted cookin or other processin.2 east, dark reen leay eetables, and oranes hae the hihest olate content.2,5
by caloric density include breers’ yeast, spinach, Romaine lettuce, turnip reens, parsley, asparaus, collards, cabbae, broccoli, lima beans, and bee lier.6
A AMA study concluded that studies hae suested that olate intake decreases risk o cardioascular dis-
58 Those ith the hihest amount
SDA reports sho that broccoli and alala sprouts contain ood olate3,4
MethylTF is the predominant orm and they are considered to be the
because studies usin olate (the natural orm) sho it orks, yet olic acid (the synthetic orm) does not. Food olate is clearly superior.
Folic Acid is Synthetic and Unnatural Folic acid accumulations may be problematic.8
ood olate is natural and is absorbed throuh a dierent pathay than olic acid,2
does not result in an accumulation o a orein substance in the body, but instead has many benets.
o olate may impair conitie unction.9 homocysteine.10-11 Since lon-term consumption o olate
Folate is an important nutrient or healthy blood the absence o any o it can trier arious orms o anemia (especially pernicious anemia).2,6
is the most important determinant in hih homocysteine leels,8
in ascular diseases such as cardioascular and other ascular disorders. The maor orms o olates ound in ood are methylTF and ormylTF.12
and supplemental olate is eectie in reducin omocysteine is hihly implicated
For many years, public health ocials hae adocated the consumption o olic acid. There are many reports that olic acid should be taken by prenant omen and may preent birth deects. Folic acid has also been claimed to help preent cardio- and cerebral-ascular diseases. et e reports hae mentioned that olic acid is unnatural, olic acid is synthetic, and that the body cannot properly conert much olic acid into a usable olate orm. Furthermore, concerns about olic acid eedin cancer are no a real concern in the 21st century, too much olic acid may kill you.
Once called itamin B9, it is more commonly
knon as pteroyllutamic acid (PA) and is a crystalline substance (no ood itamins are naturally crystalline in structure).2,13
exists in oods, yet crystalline olic acid does not.2,5,8,13 Folates also dier rom olic acid in the extent o the reduction state o the pteroyl roup, the nature o the substituents on the pteridine rin and the number o lutamyl residues attached to the pteroyl roup.5
Folate, once also knon as itamin B9,
o more than 266 mc o synthetic olic acid (PA) results in absorption o unreduced PA, hich may interere ith olate metabolism or a period o years2 A 2004 paper rom the British Medical ournal conrmed hat many natural health proessional hae knon all alon: since olic acid is unnatural and the body cannot ully conert lare amounts o it into usable olate, this articial substance can be absorbed and may hae unknon neatie conseuences in the human body.8
One o the biest scientic concerns about olic acid is that een in amounts close to ocial daily recommendations, some o it is absorbed in unreduced orm into the bloodstream ith potentially danerous
(Continued on next page) THE ORIGINAL INTERNIST NE 2016
An rish study ound that the body has trouble conertin more than 266 mc o olic acid per day.2
Consumption
Folic acid is a synthetic olate orm5 deeloped until the 20th century.2
Folic acid is chemically and as not
Subclinical deciencies Folate deciency
eases. oeerolic acid supplementation has not been shon to reduce risk o cardioascular diseases.7
This is
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