. De novo  w              w           ,        .   w,             .               w   ,       1 .2


   ,       w    w       . T           w      . ,          w    222     214   .4


        , ,    .


    w,       ,     . ,  ,            ,     


            .


Figure 3 Postnatal consequences of the Dutch Hunger Winter. T               .





         .          w        . T           .  ,  w   ,   T, T, T, T, . w        . T w,  ,        w    w        w   .21


      w, T      


    ,    .22


w           .  ,    acquired           , 12, , , , 2, ,     .2


T     


It is imperative to point out that one may have few to no SNPs which affect methylation,          methyl donors (B12, folate, etc.) he/she will have      same outcome as if many SNPs existed. ,  ,  ,               .               . T,                    .24


      ,        w. T               w  .  ,   T,  ,         ,               .


Critical Windows in Fetal Development T                  . 


   


Dutch Hunger Winter Exposure to Famine


First Second Third


First trimester                        


178


Second trimester           w 


Third trimester      


      


THE ORIGINAL INTERNIST  214


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68